The influence of mitochondria in human health and disease is a rapidly expanding topic tokidoki hello kitty blind box in the scientific literature due to their integral roles in cellular death and survival.Mitochondrial biology and alterations in function were first linked to cancer in the 1920s with the discovery of the Warburg effect.The utilization of aerobic glycolysis in ATP synthesis was the first of many observations of metabolic reprogramming in cancer.Mitochondrial dysfunction in cancer has expanded to include defects in mitochondrial genomics and biogenesis, apoptotic signaling and mitochondrial dynamics.
This review will focus on the role chocolate chip cookie purse of mitochondria and their influence on cancer initiation, progression and treatment in the lung.