OBJECTIVES High-quality research forms the basis of evidence-based practice and sets the foundation for trainees to develop critical thinking skills and approach clinical problems with an inquisitive mind.The attitudes to research however vary widely and there are significant barriers to conducting research relevant to each clinical discipline.Unde
Structure determination of a low-crystallinity covalent organic framework by three-dimensional electron diffraction
Abstract Covalent organic frameworks (COFs) have been attracting intense research due to their permanent porosity, designable architecture, and high stability.However, COFs are challenging to crystallize and their synthesis often results in tiny crystal sizes and low crystallinities, which hinders an unambiguous structure determination.Herein, we d
THE ROLE OF MITOCHONDRIA IN THE DEVELOPMENT AND PROGRESSION OF LUNG CANCER
The influence of mitochondria in human health and disease is a rapidly expanding topic tokidoki hello kitty blind box in the scientific literature due to their integral roles in cellular death and survival.Mitochondrial biology and alterations in function were first linked to cancer in the 1920s with the discovery of the Warburg effect.The utilizat
Direct costs of chronic obstructive pulmonary disease among managed care patients
Anand A Dalal1, Laura Christensen2, Fang Liu3, Aylin A Riedel31US Health Outcomes, GlaxoSmithKline, Research Triangle Park, NC, USA; 2Health Economics Outcomes Research, i3 Innovus, Ann Arbor, MI, USA; 3Health Economics Outcomes Research, i3 Innovus, Eden Prairie, MN, USAPurpose: To estimate patient- and episode-level direct costs of chronic obstru